Major League Baseball 2K6 (MLB 2K6) is a 2006 licensed baseball developed by Kush Games and published by . It was released for , , , and . This is the first time the any 2K Sports game was released for a system since the 2K3 Series of games and the first Major League Baseball 2K game as was canceled for the system along with the 2K4/ Series of games.
It has new features, such as Inside Edge, World Baseball Classic, online experience and many more. This game also features various aspects that are new to baseball games, including fans shouting, the "swing stick", showboat catches, fans catching balls, and power rankings.