The player plays as a modern-day , using a katana, twin equipment's and broad equipment as the main equipmen to the hostile creatures. Combat system is similar to or . A bar is used up when "ninja vision" or is used. The gameplay is highly cinematic, relying on to finish missions; after attacking a boss until the health bar is empty, the player must perform a finishing move, called the todome.In 2011, the inhabitants of a small Northern African village are infected by an unknown parasite, classified as "Alpha-worm", which alters its hosts' bodies and minds while increasing their strength and resilience. To prevent an outbreak, the military raid the quarantine zone and exterminate the infected, while the incident is by the government. Military intelligence forms a containment task force called GUIDE (Global United Infestation Detection and Elimination), recruiting operatives from around the world
- Four years later, a GUIDE team, including the young Ken Ogawa and led by his father Kanbe, is dispatched to to contain a massive Alpha-worm outbreak
- Following Kanbe's trail, Ken chases and defeats an Arachne creature, however Kanbe and fellow team member Kuroh, having been infected by King Worms, slaughter the entire unit
- Kanbe runs Ken through with the clan's 'Ninja Blade', narrowly missing his heart — something a master swordsman could only do on purpose
- After a quick recovery, Ken is dispatched solo back to the city.
