Sertraline is the generic form of the brand name drug Zoloft. It’s used to treat various mental health conditions, including depression, obsessive-compulsive disorder (OCD), panic attacks, post-traumatic stress disorder (PTSD), and social anxiety.
Zoloft is also prescribed to help symptoms of premenstrual dysphoric disorder, such as mood swings, bloating, irritability, and breast tenderness.
This medicine is in a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). It works by boosting levels of a natural substance called serotonin in the brain.
The U.S. Food and Drug Administration (FDA) approved Zoloft in 1991.
Everyday Health
USES
What is Zoloft (Sertraline) used for?
Depression
Obsessive Compulsive Disorder
Panic Disorder
Post Traumatic Stress Disorder
Depressive Psychosis
Premenstrual Dysphoric Disorder
Arteriosclerotic Dementia w/ Depressive Features
Social Anxiety Disorder
Dementia w/ Depressive Features
Cerner Multum
WARNINGS
What is the most important information I should know about Zoloft (Sertraline)?
You should not use sertraline if you are allergic to it, or if you also take pimozide. Do not use the if you take disulfiram (Antabuse). liquid form of sertraline
Sertraline is approved for use in children at least 6 years old, only to treat obsessive-compulsive disorder but not depression.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of sertraline on the baby.
Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop sertraline without asking your doctor.
Ask a doctor if it is safe to breastfeed while using this medicine.
Do not use sertraline if you have used an MAO inhibitor in the past 14 days.Wait at least 14 days after stopping an MAO inhibitor before you take sertraline. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.
Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with sertraline could cause a serious condition called serotonin syndrome.
Tell your doctor if you have ever had:
Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Your doctor will need to check your progress on a regular basis. Your family or caregivers should also watch for sudden changes in your behavior.
an allergy or sensitivity to aspirin, tartrazine (food dye) or latex (oral solution);
bipolar disorder (manic depression);
heart disease, high blood pressure, or a stroke;
liver or kidney disease;
seizures;
sexual problems;
glaucoma;
bleeding problems, or if you take warfarin (Coumadin, Jantoven);
long QT syndrome; or
low levels of sodium in your blood.
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